Disease feature
PheCode 401.1

PheCode 401.1

Clinical phenotype

Primary presentation

Severe vs None

Prevalence PheDASOdds ratio

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Incidence PheDASHazard ratio

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Adjustment ladder

How the estimate changes from M1 to M4

M4 is emphasized as the primary presentation model. M3 excludes BMI.

Prevalence

Odds ratios

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Incidence

Hazard ratios

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Attenuation between M3 and M4 may be scientifically informative because BMI can be conceptualized differently across questions. The atlas presents both estimates without assigning a causal role.

Dose pattern

M4 associations across OSA severity

Each row compares an OSA severity group with AHI <5 in the referred cohort.

Prevalence

OR by severity

prevalence M4 associations by OSA severity
ContrastORIntervalFDR
Incidence

HR by severity

incidence M4 associations by OSA severity
ContrastHRIntervalFDR
Prevalence PheDAS

Existing disease evidence

L1-regularized logistic models summarize disease presence before index. Odds ratios are shrunk and intervals are non-classical.

Disclosure note

Per-feature case counts are not present in the current combined output. Public data downloads remain disabled pending approved disclosure checks.

Incidence PheDAS

New-onset disease evidence

Ridge cause-specific Cox models follow at-risk participants after index. Disease-specific at-risk and event counts, stability, and proportional-hazards diagnostics appear beside each result.

Model note

Incidence M3 also includes baseline encounter rate; model labels are analysis-specific.

Interpretation

Association, not causation

The reference is a symptomatic referral group. These estimates do not measure population OSA prevalence and should not be described as causal, protective, or independent risk effects.

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